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Montelukast and psychiatric disorders in children June 2009 This study evaluated psychiatric adverse events during treatment with montelukast in children and concluded that further studies are needed to establish the magnitude of the problem.
FDA Medical Review for Singulair 10 MG Depression and insomnia were documented in a clinical study (pages 84-86 of the PF or pages 78-80 on the document)
FDA Medical Review for Singulair 5 MG Chewable Depression and insomnia were documented in children taking montelukast (Singulair) in a clinical study (page 24 of the PDF or page 21 on the document)
Canadian "Product Monograph" for SingulairHYPERKINESIA was reported as a drug related adverse experience in >1% of patients treated with SINGULAIR and at a greater incidence than in patients treated with placebo in a clinical study of 175 pediatric patients 6 months to 2 years of age, This information is not included in the "Adverse Reactions" section of Singulair's US label.
Singulair and Depression eMedTV, January 15, 2009 Depresion was reported as an adverse event in the clinical trials for Singulair
Singulair-increases-risk-of-Suicide---Dont-just-poo-poo-the-possibility David Engler, MD, The Allergy Clinic. April 2008. Dr. Engler has served two terms on the Board of Regents of the American College of Allergy, Asthma & Immunology, and has represented that organization at the A.M.A.
Churg–Strauss syndrome and leukotriene antagonist use: a respiratory perspective Thorax Online, May 2008, N. Nathani, M A Little, H Kunst, D Wilson, D R Thickett. Authors conclude that based on the available clinical evidence there is a suggestion of a causal relationship between LTA and CSS. Respiratory physicians need to be aware of the risk of CSS when treating patients with asthma with LTAs. Patients should be made aware of the signs and symptoms of CSS after initiation of LTA therapy and they should be regularly monitored for complications.
Montelukast and Churg-Strauss syndrome Swiss Med Weekly, 2004, David Conena, Jörg Leuppib, Lukas Bubendorfc, Anke Ronsdorfa, Michael Tammb, Thomas Hauserd. Almost 150 cases of LRA associated CSS have been reported by the US FDA...An as yet unknown direct pathogenic effect of these drugs appears to be possible...Given the various, inconclusive reports, a controlled study with a large number of patients is needed...clinicians should be aware of this rare but potentially severe complication of LRA.
Churg–Strauss syndrome in two patients receiving montelukast Oxford Journals, Rheumatology 2002, P. Guilpain, J.-F. Viallard, P. Lagarde, P. Cohen, M. Kambouchner, J.L. Pellegrin and L. Guillevin. Both patients presented with CSS after 4–5 months of treatment with montelukast. Neither patient received long-term systemic steroids for asthma, but both were on inhaled steroids.
Montelukast and Churg-Strauss syndrome Thorax online 2002, R Solans, J A Bosch, A Selva, R Orriols, M Vilardell. To our knowledge, no case of CSS relapse has previously been reported in association with leukotriene antagonists.
Montelukast and Churg-Strauss Syndrome Turkish Respiratory Journal, Füsun Topçu, Levent Akyıldız, Tekin Yıldız, Kenan İltumur, Faruk Oktay, Nihal Kılınç.CSS does not appear to relate to steroid tapering in our patient. Long-term data on these drugs are lacking and leukotriene's role in vasculitis remains to be elucidated. Cardiac involvement in CSS, may present as a serious course.
Asthma Risk for Behavioral, Emotional, Developmental Problems Researchers at the University of Virginia Children's Hospital evaluated data collected in a survey conducted by the Centers for Disease Control and Prevention. According to the study, parents of kids with asthma were twice as likely to report that their child has severe problems with behavior, emotions, concentration, or getting along with others. THIS ARTICLE DOES NOT DISCUSS THE ROLE OF ASTHMA MEDICATIONS AS A CONTRIBUTING FACTOR.
INFORMATION ABOUT COMPLIMENTARY AND ALTERNATIVE TREATMENTS FOR ASTHMA AND ALLERGIES
Asthma is a serious disease. If you decide to treat your or your child's asthma symptoms with natural products, consult a licensed health professional. Supplements and herbs can be harmful if used incorrectly.
